Potassium Carbonate → HCID 54335838、化合物

HRID 128319ノート

反応式

HRID 128319 の反応式
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.C(=O)([O-])[O-].[K+].[K+].CN(C)P(N(C)C)(N(C)C)=O>O>[CH2:24]1[CH2:23][CH2:22][CH2:21][CH:20]([CH2:19][CH2:18][CH2:17][CH2:16][NH:1][C:2]2[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:13][CH:14]=2)[CH2:26][CH2:25]1

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 12679HexamethylphosphoramideHCID 97826Ethyl 3-(4-aminophenyl)acrylateHCID 13131543(4-Bromobutyl)cycloheptane

生成物 1

HCID 54335838HCID 54335838、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of ethyl p-aminocinnamate, 5.9 g. 4-bromobutylcycloheptane and one equivalent of anhydrous powdered potassium carbonate in 50 ml. hexamethylphosphoramide is heated for 20 hours at 60° C. The mixture is then cooled, diluted with water and extracted with ether. The combined ether extracts are dried, filtered and evaporated. Crystallization from acetonitrile provides the title compound as white crystals.

後処理

  1. temperatureThe mixture is then cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried
  4. filtrationfiltered
  5. customevaporated
  6. customCrystallization from acetonitrile

出典と根拠

ORDレコード
ord-066ba254822146d2a4d93aa6ba85e614
出典データセット
uspto-grants-1981_03
特許番号
US04259352

反応ノート

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