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Ammonia → 2,6-Dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | o-(Trifluoromethyl)benzaldehyde | HCID 123067 | — |
| 反応物 | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2,6-Dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68120665 | 60% |
反応手順
8.7 g of 2-trifluoromethylbenzaldehyde, 16 g of γ-methoxyacetoacetic acid ethyl ester and 5 ml of aqueous concentrated ammonia in 30 ml of ethanol are heated to the boil overnight, the mixture is cooled and 2,6-dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of light brown crystals of melting point 133°-134°C, in a yield of 60% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03974278 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-34ec25078a594fb58e3f762a57550ec8 |
| 出典メモ | uspto-grants-1976_08 |