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4-(Methylsulfonyl)benzaldehyde → 2-Methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Methylsulfonyl)benzaldehyde | HCID 220376 | — |
| 反応物 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 反応物 | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68121017 | 65% |
反応手順
A solution of 9.2 g of 4-methylsulphonylbenzaldehyde, 8 g of γ-methoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ml of ethanol is heated to the boil and, after cooling, 2-methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of yellow crystals of melting point 156°-158°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03974278 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-c4a94212307643d4a19a8927daeaaf68 |
| 出典メモ | uspto-grants-1976_08 |