Acetic Anhydride → Aurone

HRID 1283375

反応式

HRID 1283375 の反応式
[O:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])[CH2:2]1.C(O[C:15](=O)[CH3:16])(=O)C>>[CH:4]1[CH:5]=[CH:6][C:15](/[CH:16]=[C:2]2/[C:3]([C:4]3[C:9]([O:1]/2)=[CH:8][CH:7]=[CH:6][CH:5]=3)=[O:10])=[CH:2][CH:3]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 23556Coumaranone

生成物 1

HCID 6537099Aurone

反応条件

温度
100 °C

実験手順

In which R1 and R2 are as defined in formula I. Thus, as shown above, a 3-coumaranone is reacted with an appropriately substituted benzaldehyde and acetic anhydride by heating at a temperature up to about 100°C. for from 1 to 3 hours. The reaction mixture is treated with ice, extracted with a nonreactive organic solvent such as ether and the product from the extract is heated at reflux for about one hour with a mineral acid, such as hydrochloric acid, an alkanol such as methanol or ethanol, and water. Cooling gives the substituted aurone product.

後処理

  1. additionThe reaction mixture is treated with ice
  2. extractionextracted with a nonreactive organic solvent such as ether
  3. temperaturethe product from the extract is heated
  4. temperatureat reflux for about one hour with a mineral acid, such as hydrochloric acid
  5. temperatureCooling

出典と根拠

ORDレコード
ord-9d1efaa494c4417a90a2aeaa22adc5de
出典データセット
uspto-grants-1976_08
特許番号
US03975380

関連ノート

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