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Triethylamine → diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]tartrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Butanedioic acid, 2,3-dihydroxy-, diethyl ester, S-(R*,R*)- | HCID 62333 | — |
| 反応物 | 4-[N-trifluoroacetyl-(2-cyclohexylethylamino)]phenylacetyl chloride | HCID 20499025 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]tartrate | HCID 20498970 | — |
反応手順
A mixture of 4-[N-trifluoroacetyl-(2-cyclohexylethylamino)]phenylacetyl chloride and 1.2 g. triethylamine in 100 ml. warm ether is treated with 2.5 g. diethyl tartrate and refluxed for 24 hours. The hot solution is filtered, the residue is washed with hot ether, and the solution is evaporated. After treatment with aqueous methanolic potassium carbonate, the product is precipitated by acidification, filtered, and dried. Crystallization from acetone yields diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]-tartrate as a white, crystalline solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259352 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-d6bcb04ee69c4d97b29d544f194fa0b0 |
| 出典メモ | uspto-grants-1981_03 |