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Chloroacetyl chloride → Thiophene-3,4-dicarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | 1H,3H-Thieno[3,4-c]furan-1,3-dione | HCID 315608 | — |
| 生成物 | Thiophene-3,4-dicarboxylic acid | HCID 255853 | — |
反応手順
A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259476 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-cdd40e584b9e4651ba74e24770d441ee |
| 出典メモ | uspto-grants-1981_03 |