Hydrochloric Acid → HCID 21409930、化合物

HRID 1283544ノート

反応式

HRID 1283544 の反応式
[CH2:1]([NH:3][CH2:4][C:5]1([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:2].[ClH:18]>CCOCC>[ClH:18].[ClH:18].[CH2:1]([NH:3][CH2:4][C:5]1([N:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21409899HCID 21409899、化合物

生成物 1

HCID 21409930HCID 21409930、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 1-[1-(Ethylaminomethyl)cyclohexyl]-4-methyl piperazine (1.5 g.,) in ether (20 ml) was added excess of ethereal HCl. The suspension was evaporated to dryness and the residual oil was re-evaporated with ethanol/ether (x2). The residue was dissolved in a minimum amount of hot ethanol, the solution was cooled and excess isopropanol was added. The solid which separated was filtered and crystallised from ethanol/isopropanol to give 1-[1-(Ethylaminomethyl)cyclohexyl]-4-methyl piperazine, dihydrochloride (0.15 g.) m.p. 231°-234°.

後処理

  1. customThe suspension was evaporated to dryness
  2. customthe residual oil was re-evaporated with ethanol/ether (x2)
  3. dissolutionThe residue was dissolved in a minimum amount of hot ethanol
  4. temperaturethe solution was cooled
  5. additionexcess isopropanol was added
  6. customThe solid which separated
  7. filtrationwas filtered
  8. customcrystallised from ethanol/isopropanol

出典と根拠

ORDレコード
ord-23211c3468a048dd880f7de711db4db4
出典データセット
uspto-grants-1976_08
特許番号
US03975443

反応ノート

読み込み中…