Sulfuric Acid → Propanamide, 2-(dimethylamino)-2-methyl-

HRID 1283546ノート

反応式

HRID 1283546 の反応式
S(=O)(=O)(O)O.[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]#[N:10].[OH-:14].[Ba+2].[OH-]>>[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]([NH2:10])=[O:14]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 6093286Barium hydroxideHCID 105108312-(Dimethylamino)-2-methylpropanenitrile

生成物 1

HCID 21409863Propanamide, 2-(dimethylamino)-2-methyl-収率 45%

反応条件

温度
90 °C

実験手順

Conc. Sulphuric acid (8 ml.) was added to 2-dimethylamino-2-methyl-propionitrile (2 g.), and was heated to 90°C and allowed to stand for five mins. The reaction mixture was added to ice cold water (100 ml.), barium hydroxide (32 g.) was added to neutralise the acid and the mixture was filtered (hyflo). The filtrate was evaporated under reduced pressure to give a solid residue which was crystallised from light petroleum (80°-100°C) to give 2-dimethylamino-2-methylpropionamide (1 g. 45%) m.p. 109°-111°C.

後処理

  1. additionwas added
  2. filtrationthe mixture was filtered (hyflo)
  3. customThe filtrate was evaporated under reduced pressure
  4. customto give a solid residue which
  5. customwas crystallised from light petroleum (80°-100°C)

出典と根拠

ORDレコード
ord-0eedefc7dbf448dab6db49e5906563a1
出典データセット
uspto-grants-1976_08
特許番号
US03975443

反応ノート

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