Sulfuric Acid → 1-Ethyl-4-(4-fluorophenyl)benzene

HRID 1283629ノート

反応式

HRID 1283629 の反応式
C(C1C=CC(C2C=CC=CC=2F)=CC=1)#C.[C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)#[CH:17].S(=O)(=O)(O)O.[H][H]>>[CH2:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)[CH3:17]

参加物

5

反応物 4

HCID 1118Sulfuric AcidHCID 42040FluretofeneHCID 196905164-Ethynyl-4'-fluoro-1,1'-biphenylHCID 178418361HCID 178418361、化合物

生成物 1

HCID 214329111-Ethyl-4-(4-fluorophenyl)benzene

実験手順

The procedure of Example 1 was repeated, except that the 1-ethynyl-4-(2-fluorophenyl)benzene was replaced with 1.5 g of 1-ethynyl-4-(4-fluorophenyl)benzene, the amount of catalyst was reduced to 0.5 g, the sulfuric acid was omitted, initial hydrogen pressure was 48 psig, and the reduction was allowed to proceed overnight. Evaporation of the benzene left a solid which was recrystallized from hexane to give 1-ethyl-4-(4-fluorophenyl)benzene, mp 60°-63°. The following elemental analysis was obtained:

後処理

  1. customEvaporation of the benzene
  2. waitleft a solid which
  3. customwas recrystallized from hexane

出典と根拠

ORDレコード
ord-393d8f860cee4e81bd68d4bb33aada1b
出典データセット
uspto-grants-1976_08
特許番号
US03975542

反応ノート

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