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Hydrochloric Acid → 3-Chloro-4-methoxybenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 3-chloro-p-anisate | HCID 123469 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Chloro-4-methoxybenzoyl chloride | HCID 4769299 | — |
反応手順
A mixture of 10.4 g. (0.052 mol.) of 3-chloro-4-methoxybenzoic acid methyl ester and 3.5 g. (0.09 mol.) of sodium hydroxide in 150 ml. of water was refluxed for two hours. The reaction mixture was cooled and acidified with 10% aqueous hydrochloric acid to precipitate 3-chloro-4-methoxybenzoic acid, m.p. 199°-202°. The acid was refluxed with thionyl chloride as described in the procedure of Example 9 to give 3-chloro-4-methoxybenzoic acid chloride, m.p. 55°-57°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03975537 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-3d84c3f678a24b7e9b92c4cbcf018d63 |
| 出典メモ | uspto-grants-1976_08 |