2-Amino-3-(trifluoromethyl)benzonitrile → 3-Amino-6-(trifluoromethyl)-1H-indazole

HRID 1283705

反応式

HRID 1283705 の反応式
[C:1]([C:3]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:4]=1[NH2:5])#[N:2].[N:14]([O-])=O.[Na+]>Cl>[NH2:2][C:1]1[C:3]2[C:4](=[CH:6][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:8][CH:9]=2)[NH:5][N:14]=1

参加物

4

反応物 2

HCID 134390282-Amino-3-(trifluoromethyl)benzonitrileHCID 23668193Sodium Nitrite

生成物 1

HCID 8179093-Amino-6-(trifluoromethyl)-1H-indazole

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒2 回

実験手順

To a mixture of 18.6 g. of 2-cyano-5-trifluoromethylaniline and 120 ml. of concentrated hydrochloric acid is added dropwise 8.0 g. of sodium nitrite in aqueous solution. The resulting diazo solution is added dropwise to 152 g. of stannous chloride in concentrated hydrochloric acid at 0° C. After allowing the mixture to stand for several hours at 0° C., it is filtered. The solid is treated with boiling water and the solution is made alkaline. The precipitate is recrystallized from benzene to give 3-amino-6-trifluoromethylindazole, M.P. 168°-169° C.

後処理

  1. additionTo a mixture of 18.6 g
  2. customat 0° C
  3. waitto stand for several hours at 0° C.
  4. filtrationit is filtered
  5. additionThe solid is treated with boiling water
  6. customThe precipitate is recrystallized from benzene

出典と根拠

ORDレコード
ord-826482f045394eba86ee79ed73efde15
出典データセット
uspto-grants-1976_08
特許番号
USRE028939

関連ノート

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