Triethylamine → N-((Phenylmethoxy)carbonyl)-L-phenylalanine ethyl ester

関与物質

反応手順

To a suspension of N-benzyloxycarbonyl-L-phenylalanine (1.5 g) and 2-ethoxycarbonyloxyimino-2-cyanoacetic acid amide (0.95 g) in ethyl acetate (20 ml), a solution of triethylamine (0.7 ml) in ethyl acetate (5 ml) is dropwise added at -10°C, and the resulting mixture is stirred at the same temperature for 20 minutes and then at room temperature for 2 hours. After allowed to stand over night, the reaction mixture is treated as in Example A to give N-benzyloxycarbonyl-L-phenylalanine ethyl ester (1.7 g) as an oil.

情報源と証拠