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Trifluoroacetic acid → 2-Pyrrolidineheptanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 1-Chloroheptane | HCID 12371 | — |
| 反応物 | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 2-Pyrrolidineheptanoic acid | HCID 21516714 | — |
反応手順
2-Pyrrolidineheptanoic acid is prepared from N-t-butoxycarbonylproline following steps A and B of Example 4 and step C of the procedure of Example 15. In step C, benzyl ω -chlorohexanoate is substituted for the 1-chloroheptane. The product thus obtained is hydrogenated in the presence of 10% palladium on charcoal and is then treated with trifluoroacetic acid, as in step E of the same procedure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03976660 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-ac43cdb103e74c488b72722a12b4803a |
| 出典メモ | uspto-grants-1976_08 |