Bis(Chloromethyl) Ether → 1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene

HRID 1283899ノート

反応式

HRID 1283899 の反応式
[F:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH:4]=O.FC1C=CC=C(OC)C=1OC.[Cl:25]COCCl>C(O)(=O)C>[F:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH2:4][Cl:25]

参加物

5

反応物 3

HCID 10967Bis(Chloromethyl) EtherHCID 6035882-Fluoro-3,4-dimethoxybenzaldehydeHCID 27589791-Fluoro-2,3-dimethoxybenzene

生成物 1

HCID 2374111-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The 2-fluoroveratraldehyde used as indicated above is prepared as follows: 3-fluoroveratrole is reacted with monochloromethyl ether in glacial acetic acid to give 2-fluoro-3,4-dimethoxybenzyl chloride which is treated with hexamethylenetetramine in chloroform followed by refluxing in 50% acetic acid to yield the 2-fluoroveratraldehyde.

後処理

  1. customabove is prepared

出典と根拠

ORDレコード
ord-698568d1285144f38373b489a08d7a01
出典データセット
uspto-grants-1976_08
特許番号
US03976695

反応ノート

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