Ammonia → N-(2-Phenylpropan-2-yl)glycinamide

HRID 1283944ノート

反応式

HRID 1283944 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]([CH3:14])([CH3:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].[NH3:15]>C(O)C>[CH3:13][C:6]([NH:5][C:3](=[O:4])[CH2:2][NH2:15])([CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 13142344HCID 13142344、化合物

生成物 1

HCID 21516969N-(2-Phenylpropan-2-yl)glycinamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-chloro-N-(α,α-dimethylbenzyl)-acetamide (11.5 g; 0.054 mole) in ethanol (300 ml) was cooled to 0°C. The solution was saturated with ammonia (5 hours). Stirring was continued at room temperature for about 6 days. The solvent was removed under vacuum. The oily residue was taken up in 2N HCl and filtered. The filtrate was made alkaline by the addition of 2N NaOH. The alkaline phase was extracted three times with ether. The organic layer was dried over, anhydrous Na2SO4 and the solvent was evaporated. The N1 -(α,α-dimethylbenzyl)glycineamide was obtained as a light brown oil. Yield: 6.5 g (62.5 %).

後処理

  1. customThe solvent was removed under vacuum
  2. filtrationfiltered
  3. additionby the addition of 2N NaOH
  4. extractionThe alkaline phase was extracted three times with ether
  5. dry with materialThe organic layer was dried over, anhydrous Na2SO4
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-cab9a6b5a8b748b48da3e766d871f85a
出典データセット
uspto-grants-1976_08
特許番号
US03976771

反応ノート

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