Hydrochloric Acid → 5-Amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochloride

HRID 1284030ノート

反応式

HRID 1284030 の反応式
C(O[C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)C.[OH-].[NH4+:17].[ClH:18].CCOCC>C(O)C>[NH2:17][C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1.[ClH:18].[NH2:17][C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 14923Ammonium HydroxideHCID 215155225-Ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

生成物 2

HCID 215155205-Amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochlorideHCID 215155215-Amino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a suspension of 5-ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline (200 mg, 1 mmole), described in Example 5, in ethanol (2 ml), aqueous ammonium hydroxide (25%, 0.5 ml, 1.4 mmole) is added followed by 2.3 N HCl in ethanol (0.5 ml). The mixture is heated at reflux for 0.5 hour, then ether is added and the light green crystalline precipitate collected to give the hydrochloride salt of the title compound, 5-amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochloride, mp 227° - 228°C.

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 0.5 hour
  3. customthe light green crystalline precipitate collected

出典と根拠

ORDレコード
ord-62f82ea11cf54520bb531ed43a5f9e8e
出典データセット
uspto-grants-1976_08
特許番号
US03978066

反応ノート

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