Acetic Anhydride → Pyrrolo(4,3,2-de)(1,2,4)triazolo(3,4-a)isoquinoline, 4,6-dihydro-8-methyl-

反応式

Cl.[NH:2]([C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)[NH2:3].[C:16](OC(=O)C)(=O)[CH3:17].C(=O)(O)[O-].[Na+]>>[CH3:16][C:17]1[N:5]2[CH2:6][C:7]3[C:8]4[C:9]([NH:14][CH:15]=3)=[CH:10][CH:11]=[CH:12][C:13]=4[C:4]2=[N:2][N:3]=1

参加物

反応物 3

HCID 7918Acetic Anhydride

HCID 516892Sodium Bicarbonate

HCID 3041086Pyrrolo(4,3,2-de)isoquinolin-5(1H)-one, 3,4-dihydro-, hydrazone, monohydrochloride

生成物 1

HCID 3041158Pyrrolo(4,3,2-de)(1,2,4)triazolo(3,4-a)isoquinoline, 4,6-dihydro-8-methyl-

実験手順

5-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline hydrochloride (50 mg), described in Example 8, is heated at reflux with 3 ml of acetic anhydride for 2 hours. The mixture is cooled and then poured into a saturated solution of sodium bicarbonate. The resulting precipitate is collected and then dissolved in methanol. This solution is rendered acidic by the addition of HCl in ether. The mixture is treated with charcoal and concentrated to give the title compound.