Acetone → 2-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

HRID 1284275ノート

反応式

HRID 1284275 の反応式
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br)([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C-:21]#[N:22].[K+].CC(C)=O>O>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][C:21]#[N:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 180AcetoneHCID 9032Potassium CyanideHCID 203722852-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzyl bromide

生成物 1

HCID 203722272-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-(α,α,β ,β-Tetrafluorophenethyl)benzyl bromide, 3.5 g. (0.01 mole), and 2.0 g. (0.0308 mole) of potassium cyanide are dissolved in 35 ml. of acetone - 5 ml. of water and the solution is heated to refluxing for about 18 hours. The organic phase is separated, acetone is distilled under reduced pressure, and the residual oil is dissolved in benzene. Evaporation of the washed and dried benzene extract under reduced pressure leaves the product as the residual brown oil.

後処理

  1. temperatureto refluxing for about 18 hours
  2. customThe organic phase is separated
  3. distillationacetone is distilled under reduced pressure
  4. dissolutionthe residual oil is dissolved in benzene
  5. customEvaporation of the
  6. washwashed
  7. extractiondried benzene extract under reduced pressure
  8. customleaves the product as the residual brown oil

出典と根拠

ORDレコード
ord-ff7cbf6f41f344f09120b13f609ea1f9
出典データセット
uspto-grants-1976_08
特許番号
US03978127

反応ノート

読み込み中…