Water → 1-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea

HRID 1284566

反応式

HRID 1284566 の反応式
[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:12]([NH:20][C:21](=[O:29])[NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C.O>CN(C)C=O>[C:12]([NH:20][C:21]([NH:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:8][C:7]2[CH:10]=[CH:11][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)[CH2:25][CH2:24]1)=[O:29])(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 749164-Isopropylbenzyl chlorideHCID 126085824-Benzoylureidopiperidine

生成物 1

HCID 129423021-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Isopropylbenzyl chloride (0.84 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate.

後処理

  1. filtrationthe precipitated solid filtered off
  2. filtrationThe title compound was filtered off
  3. dry with materialdried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate

出典と根拠

ORDレコード
ord-0cf3f0eb8c4c4f149dfd4dd387a006c3
出典データセット
uspto-grants-1986_01
特許番号
US04563466

関連ノート

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