化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 4-[1-(p-Fluorophenyl)-1H-1,2,4-triazol-5-yl]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| 反応物 | N-Dimethylaminomethylene-isonicotinamide | HCID 12569643 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-[1-(p-Fluorophenyl)-1H-1,2,4-triazol-5-yl]pyridine | HCID 12850300 | — |
反応手順
A 6.0 g. portion of N-(dimethylaminomethylene)isonicotinamide is added to a mixture prepared by adding 6.05 g. of p-fluorophenylhydrazine hydrochloride to 80 ml. of 30% aqueous acetic acid, 40 ml. of p-dioxane and 7.5 ml. of 5 N sodium hydroxide. The mixture is heated to reflux for 1.5 hours, poured into water and allowed to stand overnight. Extraction with ether gives a dark solid which is recrystallized from acetone-hexane giving 1.7 g. of the desired product, mp. 114°-115° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259504 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-fa256fbfaab440ac832c11dd4d81f2db |
| 出典メモ | uspto-grants-1981_03 |