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Aminoisobutyric acid → 5-Isopropylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aminoisobutyric acid | HCID 6119 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| 生成物 | 5-Isopropylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013378 | — |
反応手順
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol), triethylamine (0.43 mL; 3.1 mmol) and 2-aminoisobutyric acid (320 mg; 3.1 mmol) under microwave irradiation for 6 hr according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-isopropylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (28 mg, 29%) as an off-white powder. ES-HRMS m/e calcd for C18H29N4O (M+H+) 317.2336, found 317.2334.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728029B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-998eec4678a34453b962037b0f34f3c6 |
| 出典メモ | uspto-grants-2010_06 |