Methanol → Methyl 5-chloro-2-nitrobenzoate
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:14]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:14])=[O:8]参加物
3
実験手順
5-Chloro-2-nitrobenzoic acid (20.1 g,; 0.10 mol), is dissolved in anhydrous methanol (100 ml) and anhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature. The reaction mixture is then poured into water and the aqueous mixture triturated with hexane, the hexane layer decanted, dried (anhd. MgSO4) and the solvent removed under vacuum to afford 11.7 g of methyl 5-chloro-2-nitrobenzoate, mp 50°-51° C.
後処理
- customanhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature
- additionThe reaction mixture is then poured into water
- customthe aqueous mixture triturated with hexane
- customthe hexane layer decanted
- dry with materialdried (anhd. MgSO4)
- customthe solvent removed under vacuum
出典と根拠
- ORDレコード
- ord-c210b6f1d1844ee9889f11ccfe0a161c
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04259510
反応ノート
読み込み中…