Methanol → Methyl 5-chloro-2-nitrobenzoate

HRID 128477

反応式

HRID 128477 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:14]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:14])=[O:8]

参加物

3

反応物 2

HCID 887MethanolHCID 172865-Chloro-2-nitrobenzoic acid

生成物 1

HCID 171018Methyl 5-chloro-2-nitrobenzoate

実験手順

5-Chloro-2-nitrobenzoic acid (20.1 g,; 0.10 mol), is dissolved in anhydrous methanol (100 ml) and anhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature. The reaction mixture is then poured into water and the aqueous mixture triturated with hexane, the hexane layer decanted, dried (anhd. MgSO4) and the solvent removed under vacuum to afford 11.7 g of methyl 5-chloro-2-nitrobenzoate, mp 50°-51° C.

後処理

  1. customanhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature
  2. additionThe reaction mixture is then poured into water
  3. customthe aqueous mixture triturated with hexane
  4. customthe hexane layer decanted
  5. dry with materialdried (anhd. MgSO4)
  6. customthe solvent removed under vacuum

出典と根拠

ORDレコード
ord-c210b6f1d1844ee9889f11ccfe0a161c
出典データセット
uspto-grants-1981_03
特許番号
US04259510

関連ノート

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