Hydrochloric Acid → N-Methyl-4-[(trifluoromethanesulfonyl)amino]benzene-1-sulfonamide
反応式
[CH3:1][NH2:2].[F:3][C:4]([F:20])([F:19])[S:5]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1)(=[O:7])=[O:6].Cl>O>[CH3:1][NH:2][S:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:8][S:5]([C:4]([F:20])([F:19])[F:3])(=[O:7])=[O:6])=[CH:10][CH:11]=1)(=[O:17])=[O:16]参加物
5
実験手順
A mixture of a 40% aqueous solution of methylamine (0.7 g), 4-(trifluoromethanesulfonamido)benzenesulfonyl chloride (1.5 g) and water (20 ml) was allowed to stand overnight and made acidic with hydrochloric acid to precipitate crystals, which were then recrystallized from a mixture of water and ethanol to give 0.65 g of N-methyl-4-(trifluoromethanesulfonamido)benzenesulfonamide. M.P., 156°-157° C.
後処理
- customto precipitate crystals, which
- customwere then recrystallized from a mixture of water and ethanol
出典と根拠
- ORDレコード
- ord-8cb07c34bc3b4754b46104e264120a29
- 出典データセット
- uspto-grants-1986_01
- 特許番号
- US04564386
反応ノート
読み込み中…