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Monobenzone → 4-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Monobenzone | HCID 7638 | — |
| 反応物 | 1-Chloro-2-nitro-4-(trifluoromethoxy)benzene | HCID 23297211 | — |
| 反応物 | Potassium methoxide | HCID 23664618 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether | HCID 23469827 | — |
反応手順
To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259532 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-1391ff6e4cd44424a79ed88c9d8f6738 |
| 出典メモ | uspto-grants-1981_03 |