Methanesulfonic Acid → 2,3-Dihydro-2-methyl-1H-indol-1-amine monomethanesulphonate

反応式

[NH2:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[CH3:11].[CH3:12][S:13]([OH:16])(=[O:15])=[O:14]>C(O)(C)C>[CH3:12][S:13]([OH:16])(=[O:15])=[O:14].[NH2:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[CH3:11]

参加物

反応条件

温度: 0 °C

実験手順

10 g of crude 1-amino-2-methylindoline (made as described in Example 1) was dissolved in 40 ml of isopropanol. 6.75 g of methanesulfonic acid was added and the solution was cooled to about 0° C. to obtain crystals of 1-amino-2-methylindoline methanesulfonate which was isolated by filtration. The crystals were then washed by slurrying with fresh isopropanol and dried at 20° C. Melting range of product compound was 170°-2° C.