Diethylamine → 5-Diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

HRID 12850ノート

反応式

HRID 12850 の反応式
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([CH3:20])[C:18]=1Cl)=[O:13])[CH2:8]2.[CH2:21]([NH:23][CH2:24][CH3:25])[CH3:22]>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([CH3:20])[C:18]=1[N:23]([CH2:24][CH3:25])[CH2:21][CH3:22])=[O:13])[CH2:8]2

参加物

3

反応物 2

HCID 8021DiethylamineHCID 250135435-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

生成物 1

HCID 250142485-Diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

実験手順

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and diethylamine (0.32 mL; 3.1 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (16 mg, 16%) as an off-white powder. ES-MS m/e calcd for C19H31N4O (M+H+) 331, found 331.

後処理

  1. temperatureHeating
  2. customunder microwave irradiation
  3. customprovided
  4. customafter purification by reverse phase HPLC, 5-diethylamino-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (16 mg, 16%) as an off-white powder

出典と根拠

ORDレコード
ord-deb484043d9b43fdb95c008e96681372
出典データセット
uspto-grants-2010_06
特許番号
US07728029B2

反応ノート

読み込み中…