N-[N-benzyloxycarbonyl-L-prolyl]morpholine → Morpholin-4-yl-(S)-pyrrolidin-2-yl-methanone
反応式
C(OC([N:11]1[CH2:23][CH2:22][CH2:21][C@H:12]1[C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14])=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH:11]1[CH2:23][CH2:22][CH2:21][C@H:12]1[C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14]参加物
5
実験手順
In 100 ml of ethanol was suspended 4.9 g of compound (83) and after adding thereto 250 mg of 10% palladium carbon, the mixture was stirred for 4 hours in a hydrogen stream. After filtering off 10% palladium-carbon, ethanol was distilled off under reduced pressure from the filtrate to provide 2.8 g of crude N-(L-prolyl)morpholine (84).
後処理
- additionafter adding
- filtrationAfter filtering off 10% palladium-carbon, ethanol
- distillationwas distilled off under reduced pressure from the filtrate
出典と根拠
- ORDレコード
- ord-6a2b92a9d7e84322a83770962e6bdd87
- 出典データセット
- uspto-grants-1986_01
- 特許番号
- US04564609
反応ノート
読み込み中…