化工社化工社 化学情報印刷レポート · 研究参考用
Oxalyl chloride → Benzeneacetyl chloride, 4-bromo-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | Benzeneacetic acid, 4-bromo- | HCID 74654 | — |
| 反応物 | 6-Bromo-2-tetralone | HCID 2733553 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzeneacetyl chloride, 4-bromo- | HCID 181552 | — |
反応手順
The synthesis of 6-bromo-2-tetralone is accomplished by dissolving 4-bromophenylacetic acid in methylene chloride and dimethyl formamide, under nitrogen. Oxalyl chloride is added and the mixture is stirred under a positive nitrogen atmosphere to produce the 4-bromo-phenylacetyl chloride, at a yield which typically is better than 99%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05464762 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-76ffd24e304642158af2cc014d8e9207 |
| 出典メモ | uspto-grants-1995_11 |