p-Toluenesulfonic acid monohydrate → 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate

HRID 1285127ノート

反応式

HRID 1285127 の反応式
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.O.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([OH:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1>CO>[C:16]1([CH3:26])[CH:17]=[CH:18][C:19]([S:22]([OH:25])(=[O:23])=[O:24])=[CH:20][CH:21]=1.[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

生成物 1

HCID 202498855-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate収率 62.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (0.88 g) in methanol (30 ml), p-toluenesulfonic acid monohydrate (0.97 g) was gradually added. The reaction mixture was stirred at room temperature for 30 minutes. Methanol was removed under reduced pressure and the residue was recrystallized from ethanol to give 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate (1 g, yield 62.5%) as yellow fine needles.

後処理

  1. customMethanol was removed under reduced pressure
  2. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-ac70f367dd39476eb09431d1f6e3527f
出典データセット
uspto-grants-1986_01
特許番号
US04565813

反応ノート

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