Hydrochloric Acid → HCID 10037407、化合物

HRID 1285128ノート

反応式

HRID 1285128 の反応式
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.[ClH:15]>CO>[ClH:15].[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

生成物 1

HCID 10037407HCID 10037407、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (5 g) in methanol (500 ml), 12N hydrochloric acid (4 ml) was added dropwise with stirring at room temperature. The reaction mixture was stirred at room temperature for 1 hour and then concentrated in vacuo. Tetrahydrofuran (200 ml) was added and the reaction mixture was stirred at room temperature for 10 minutes, and then filtered. The residue was recrystallized from ethanol to give 4.6 g of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one hydrochloride as pale yellow needles.

後処理

  1. stirringThe reaction mixture was stirred at room temperature for 1 hour
  2. concentrationconcentrated in vacuo
  3. additionTetrahydrofuran (200 ml) was added
  4. stirringthe reaction mixture was stirred at room temperature for 10 minutes
  5. filtrationfiltered
  6. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-c42afcba0ee649bfa06367f523f8df78
出典データセット
uspto-grants-1986_01
特許番号
US04565813

反応ノート

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