Diethylamine → 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt

HRID 1285164ノート

反応式

HRID 1285164 の反応式
[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][N:9]2[C:18]3[C:17](=[O:19])[N:15]([CH3:16])[C:14](=[O:20])[N:13]([CH3:21])[C:12]=3[N:11]=[CH:10]2)[N:4]=1.[CH2:22]([NH:24][CH2:25][CH3:26])[CH3:23]>C1(C)C=CC=CC=1>[ClH:1].[CH2:22]([N:24]([CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][N:9]2[C:18]3[C:17](=[O:19])[N:15]([CH3:16])[C:14](=[O:20])[N:13]([CH3:21])[C:12]=3[N:11]=[CH:10]2)[N:4]=1)[CH2:25][CH3:26])[CH3:23]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 202498997-[(5-Chloromethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline

生成物 1

HCID 202499047-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

9.0 g. of 7-[(5-chloromethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline, 6 cm3 diethylamine and 50 cm3 toluene are heated on water bath for 8 hours under stirring. The mixture is evaporated at reduced pressure and the residue is washed with water, dissolved in 50 cm3 hot ethanol, treated with activated charcoal and treated with ethanol in hydrochloric acid. 8.3 g of 7-[(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt are obtained. M.p.: 207°-210° C.

後処理

  1. customThe mixture is evaporated at reduced pressure
  2. washthe residue is washed with water
  3. dissolutiondissolved in 50 cm3 hot ethanol
  4. additiontreated with activated charcoal
  5. additiontreated with ethanol in hydrochloric acid

出典と根拠

ORDレコード
ord-78a7ee4f793449e9bdd6877a0a10ff67
出典データセット
uspto-grants-1986_01
特許番号
US04565817

反応ノート

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