化工社化工社 化学情報印刷レポート · 研究参考用
Glycine, N,N-diethyl-, ethyl ester → 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glycine, N,N-diethyl-, ethyl ester | HCID 75843 | — |
| 反応物 | 2-(Theophyllin-7-yl)-acetamidoxime | HCID 3057490 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline | HCID 20249905 | 80% |
反応手順
5.04 g. of 2-(theophyllin-7-yl)-acetamidoxime, 2.16 g. of sodium methylate, 6.37 g. of diethylamino acetic acid ethylester and 80 cm3 methanol are stirred for 10 hours at 100° C. in a closed system under pressure. 5.2 g. (80% yield) of 7-[(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline are obtained. m.p.: 69°-70° C. (cyclohexane).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04565817 |
| 出典データセット | uspto-grants-1986_01 |
| ORD ID | ord-7ba5ad3d9278458889cbef3ce6d90db8 |
| 出典メモ | uspto-grants-1986_01 |