1-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1) → Doxepin

HRID 1285337

反応式

HRID 1285337 の反応式
[CH3:1][N:2]([CH2:4][CH2:5][CH:6]=[C:7]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[O:15][CH2:14][C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)[CH3:3].Cl.C(=O)(O)[O-].[Na+]>O>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]=[C:7]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[O:15][CH2:14][C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)[CH3:3]

参加物

4

反応物 2

HCID 146751-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1)HCID 516892Sodium Bicarbonate

生成物 1

HCID 3158Doxepin

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Doxepin hydrochloride (10 g., 0.032 mol) was dissolved in 50 ml. H2O. Sodium bicarbonate (3.2 g., 0.038 mol) suspended in 25 ml. of H2O was added with stirring, and the mixture stirred for 20 minutes and then extracted 3×50 ml. ether. The ether extracts were combined, dried (Na2SO4) and evaporated in vacuo to yield doxepin as an oil (8.33 g.).

後処理

  1. stirringthe mixture stirred for 20 minutes
  2. extractionextracted 3×50 ml
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-c91b9163108f4b619c0fca596a0e1400
出典データセット
uspto-grants-1986_01
特許番号
US04567179

関連ノート

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