Ammonium Hydroxide → Ranolazine
反応式
Cl.Cl.[CH3:3][O:4][C:5]1[CH:33]=[CH:32][CH:31]=[CH:30][C:6]=1[O:7][CH2:8][CH:9]([OH:29])[CH2:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([NH:20][C:21]2[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:28])=[O:19])[CH2:13][CH2:12]1.[OH-].[NH4+]>O>[CH3:3][O:4][C:5]1[CH:33]=[CH:32][CH:31]=[CH:30][C:6]=1[O:7][CH2:8][CH:9]([OH:29])[CH2:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([NH:20][C:21]2[C:22]([CH3:28])=[CH:23][CH:24]=[CH:25][C:26]=2[CH3:27])=[O:19])[CH2:13][CH2:12]1参加物
4
実験手順
A solution of 3.5 g of 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt in water (50 ml) is adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride is evaporated to afford 3 g of 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine as the free base.