関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (+-)-3,4-Dimethoxyamphetamine | HCID 8423 | — |
| 反応物 | Glycidol | HCID 11164 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | 3-[3-(3,4-Dimethoxyphenyl)-2-propylamino]1,2-propanediol | HCID 53772682 | — |
反応手順
A solution of 3-(3,4-dimethoxyphenyl)-2-propylamine (20.0 g., 0.10 m.) in isopropanol (20 ml.) is heated to 50° C. while a solution of glycidol (5.0 g., 0.067 m.) in isopropanol (5 ml.) is added over 15 minutes. The mixture is stirred at 50° C. for 0.5 hours and then at 70° C. for 16 hours. The solvent is concentrated under reduced pressure and the residue is chromatographed on silica gel, eluting with 10% MeOH--CHCl3 saturated with NH3 to yield (I) weighing 14.37 g. (80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04567276 |
|---|
| 出典データセット | uspto-grants-1986_01 |
|---|
| ORD ID | ord-74792e90ea7c4b5b859c225590ac411b |
|---|
| 出典メモ | uspto-grants-1986_01 |
|---|
