Hydrochloric Acid → 2-Methoxy-4-(4-piperidyloxy)benzoic acid

HRID 128583ノート

反応式

HRID 128583 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 105458744-((1-(Tert-butoxycarbonyl)piperidin-4-YL)oxy)-2-methoxybenzoic acid

生成物 1

HCID 189141672-Methoxy-4-(4-piperidyloxy)benzoic acid

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.

後処理

  1. customThe mixture was evaporated in vacuo
  2. concentrationthe residue concentrated from ether three times

出典と根拠

ORDレコード
ord-6b356e6778eb45fba5460e10af218b03
出典データセット
uspto-grants-1995_11
特許番号
US05464788

反応ノート

読み込み中…