関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| 生成物 | Diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate | HCID 19374312 | — |
反応手順
A mixture of 6-trifluoromethylpyridin-2-amine (17.2 g) and diethyl ethoxymethylenemalonate (22.9 g) was heated at 95° C., under vacuum for 8 hours. The mixture was cooled and diluted with petroleum ether b.p. 60°-80° C. (50 ml). The mixture was filtered and the residue was recrystallised from IMS to give diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate, m.p. 125°-128° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05464781 |
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| 出典データセット | uspto-grants-1995_11 |
|---|
| ORD ID | ord-2745d60f2e3c4211bec208894ff000c1 |
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| 出典メモ | uspto-grants-1995_11 |
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