Furfural → Methyl 3-((furan-2-ylmethyl)amino)propanoate

反応式

S1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11].Cl.NCCC(OC)=[O:19].C(=O)C1OC=CC=1>>[O:19]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11]

参加物

反応物 3

HCID 7362Furfural

HCID 2734767Methyl 3-aminopropanoate hydrochloride

HCID 23369385HCID 23369385、化合物

生成物 1

HCID 21824744Methyl 3-((furan-2-ylmethyl)amino)propanoate

実験手順

Methyl 3-[(2-furanylmethyl)amino]propanoate (22) was prepared in the manner methyl 3-[(2-thienylmethyl)amino]propanoate (15) was prepared, as described above in Example 15, on a 6.5 mmol scale from methyl β-alaninate hydrochloride and furfural to yield 0.28 g (28%) of product.