Ethanone, 1-(2,4,6-trimethylphenyl)- → 2-Bromo-1-mesitylethanone

HRID 128685

反応式

HRID 128685 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[C:10](=[O:12])[CH3:11].[Br:13]Br>C(O)(=O)C>[Br:13][CH2:11][C:10]([C:3]1[C:4]([CH3:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1])=[O:12]

参加物

4

反応物 2

HCID 15461Ethanone, 1-(2,4,6-trimethylphenyl)-HCID 24408Bromine

生成物 1

HCID 2194802-Bromo-1-mesitylethanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate.

後処理

  1. temperaturewhile maintaining the reaction medium at a temperature below 10° C
  2. additionWhen the addition
  3. customto return to room temperature
  4. customleave at this temperature for 2 hours
  5. extractionextract the aqueous phase with ethyl ether
  6. washWash the organic extracts with saturated aqueous sodium bicarbonate solution
  7. dry with materialwith salt water, and dry over anhydrous magnesium sulphate

出典と根拠

ORDレコード
ord-1d73ba4322e04fd2a72493a5e232af53
出典データセット
uspto-grants-1995_11
特許番号
US05464847

関連ノート

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