Hydrochloric Acid → HCID 19374875、化合物

HRID 128690ノート

反応式

HRID 128690 の反応式
Cl.C([NH:10][C:11](=[S:25])[N:12]([CH:16]([C:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[Cl:24])[CH3:17])[CH2:13][CH2:14][CH3:15])(=O)C1C=CC=CC=1>O>[Cl:24][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][C:18]=1[CH:16]([N:12]([CH2:13][CH2:14][CH3:15])[C:11]([NH2:10])=[S:25])[CH3:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 19374853HCID 19374853、化合物

生成物 1

HCID 19374875HCID 19374875、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Add 6 ml of 32% hydrochloric acid to 1.18 g of the compound obtained in Step A. Bring the reaction medium to 80° C. for one hour, then cool and add water. Extract with methylene chloride and discard the organic phase. Alkanilise the aqueous phase with sodium carbonate and extract with methylene chloride. Dry the organic phase and evaporate under vacuum. Purify the residue by chromatography on a silica column, using a mixture of methylene chloride and methanol (98:2 V/V) as eluent.

後処理

  1. temperaturecool
  2. extractionExtract with methylene chloride
  3. extractionAlkanilise the aqueous phase with sodium carbonate and extract with methylene chloride
  4. customDry the organic phase
  5. customevaporate under vacuum
  6. customPurify the residue by chromatography on a silica column
  7. additiona mixture of methylene chloride and methanol (98:2 V/V) as eluent

出典と根拠

ORDレコード
ord-0a6fbf346934482d880efff9a5832b05
出典データセット
uspto-grants-1995_11
特許番号
US05464847

反応ノート

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