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(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| 反応物 | 4-Bromo-5-methyl-1,2-oxazol-3-amine | HCID 2774464 | — |
| 生成物 | N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide | HCID 15453175 | 5% |
反応手順
N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was prepared, using the method in Example 1 b, from 3-amino-4-bromo-5-methylisoxazole and 4-biphenylsulfonyl chloride in 5% yield. The product (m.p. 154°-156° C.) was isolated in 51% yield by column chromatography, after recrystallization from ethyl acetate/hexanes. N-(4-Biphenylsulfonyl)-No(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was obtained in 51% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05464853 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-07f9636ed4bc404cb5fdb496e88c19bf |
| 出典メモ | uspto-grants-1995_11 |