HCID 12235831、化合物 → 2-[2-(Piperidin-1-yl)ethyl]aniline
反応式
[CH:1]1[C:6]2[CH2:7][CH2:8][N:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]3=[N:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[H][H]>[Pt]=O.CO>[NH2:11][C:5]1[CH:4]=[CH:3][CH:2]=[CH:1][C:6]=1[CH2:7][CH2:8][N:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:10]1参加物
5
実験手順
Platinum oxide catalyst (1.0 g) is added to a solution of 11,12-dihydropyrido[2,1-b][1,3]benzodiazepine (20.0 g) in methanol (550 ml). Hydrogen gas (about 50 psig) is added and hydrogen uptake is completed in about 1 and 2 hours. The catalyst is filtered off, and the filtrate is concentrated to yield 22.0 g of material that crystallizes spontaneously, melting point 36°-38° C. Recrystallization from 150 ml of pentane yields 16.0 g of the title compound, melting point 39°-41° C.
後処理
- customis completed in about 1 and 2 hours
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-668e8065c14d4d5d8e589d3912ecbf00
- 出典データセット
- uspto-grants-1976_10
- 特許番号
- US03984421
反応ノート
読み込み中…