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Acetic Acid → 4-Thiazolidinone, 5-[(2,3-dimethoxyphenyl)methylene]-2-thioxo-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 2,3-Dimethoxybenzaldehyde | HCID 66581 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Rhodanine | HCID 1201546 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Thiazolidinone, 5-[(2,3-dimethoxyphenyl)methylene]-2-thioxo- | HCID 4602117 | 95.6% |
反応手順
A mixture of 2,3-dimethoxybenzaldehyde (5.2 g, 30 mmoles), rhodanine (4.0 g, 29 mmoles), sodium acetate (8.4 g, 102 mmoles), and acetic acid (50 ml) is stirred under an inert atmosphere and heated to reflux. After 4 hours the mixture is stirred into water (250 ml) and the precipitate is filtered off, rinsed successively with water (3X), ethanol (2X), and ether (2X), and dried to afford the pure product (7.8 g), mp 268°-269° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05464856 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-2a1b9a28b05d49ec9b038ce22124b7f3 |
| 出典メモ | uspto-grants-1995_11 |