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Acetic Acid → 5-[(4-Hydroxy-3-methoxyphenyl)methylene]-1-methyl-2,4-imidazolidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Beta-Alanine | HCID 239 | — |
| 反応物 | Vanillin | HCID 1183 | — |
| 反応物 | 1-Methylhydantoin | HCID 69217 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-[(4-Hydroxy-3-methoxyphenyl)methylene]-1-methyl-2,4-imidazolidinedione | HCID 54385620 | 14.8% |
反応手順
A mixture of 4-hydroxy-3-methoxybenzaldehyde (4.6 g, 30 mmoles), 1-methyl hydantoin (3.5 g, 30 mmoles), β-alanine (1.4 g, 16 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 8 hours the mixture is stirred into water (300 ml) and the precipitate filtered off, rinsed successively with water (3X), ethanol (2X), and ether (2X), and dried. Recrystallization from acetonitrile gave the pure product (1.1 g), mp 197°-198° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05464856 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-f0a802d59c9c4788a1516338c94a138d |
| 出典メモ | uspto-grants-1995_11 |