Sodium Methoxide → 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
反応式
[CH3:1][NH:2][C:3]1[C:4](=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:5]([N:7]1[CH2:14][CH2:13][CH2:12][C@H:8]1[C:9](O)=[O:10])=[O:6].C[O-].[Na+]>C(O)C>[CH3:1][N:2]1[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5](=[O:6])[N:7]2[CH2:14][CH2:13][CH2:12][CH:8]2[C:9]1=[O:10]参加物
4
実験手順
Ten grams of the ethyl ester of 1-(N-methylanthraniloyl)proline is dissolved in 100 ml. of ethanol and 3.0 g. of sodium methylate is added. The reaction mixture is heated at reflux temperature for 8 hours and concentrated to remove the solvent. The residue is shaken with benzene and the benzene solution is washed twice with water and concentrated. The residue is purified by recrystallization from ethyl acetate.
後処理
- temperatureThe reaction mixture is heated
- temperatureat reflux temperature for 8 hours
- concentrationconcentrated
- customto remove the solvent
- washthe benzene solution is washed twice with water
- concentrationconcentrated
- customThe residue is purified by recrystallization from ethyl acetate
出典と根拠
- ORDレコード
- ord-f252478c956e4403bd9e7b6a8f32e2b3
- 出典データセット
- uspto-grants-1976_10
- 特許番号
- US03985732
反応ノート
読み込み中…