Sodium Bromide → HCID 100834、化合物

HRID 1287707ノート

反応式

HRID 1287707 の反応式
S(O[CH2:12][CH2:13][CH2:14][CH:15]=[CH:16][C:17]#[C:18][CH2:19][CH3:20])(C1C=CC(C)=CC=1)(=O)=O.[Br-:21].[Na+]>CN(C)C=O>[Br:21][CH2:12][CH2:13][CH2:14][CH:15]=[CH:16][C:17]#[C:18][CH2:19][CH3:20]

参加物

4

反応物 2

HCID 253881Sodium BromideHCID 53748711HCID 53748711、化合物

生成物 1

HCID 100834HCID 100834、化合物収率 84%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 42.7 g. of 1-tosyloxynon-4-en-6-yne (0.14 moles) in 150 ml. of anhydrous dimethylformamide is added 18.7 g. of sodium bromide (0.16 moles) and the mixture is heated at 75° for 2 hour and then allowed to stir overnight at room temperature. The reaction mixture is then diluted with 200 ml. of ice water and extracted with pentane. The pentane extract is washed with water and dried over sodium sulfate. Evaporation of solvent in vacuo and distillation of the residual oil gave 34.3 g. of 1-bromonon-4-en-6-yne (84% yield) b.p. 52°-55° at 0.15 mm.

後処理

  1. additionThe reaction mixture is then diluted with 200 ml
  2. extractionof ice water and extracted with pentane
  3. extractionThe pentane extract
  4. washis washed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of solvent
  7. distillationin vacuo and distillation of the residual oil
  8. customgave 34.3 g

出典と根拠

ORDレコード
ord-0878c71cce2b4c99a2ea6b16e61d5e97
出典データセット
uspto-grants-1976_10
特許番号
US03985813

反応ノート

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