Ethyl formate → N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]formamide

HRID 1287845ノート

反応式

HRID 1287845 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:11]([NH2:23])[CH:10]=1)=[O:8].[CH:24](OCC)=[O:25]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:11]([NH:23][CH:24]=[O:25])[CH:10]=1)=[O:8]

参加物

3

反応物 2

HCID 8025Ethyl formateHCID 538809743-Amino-4-benzyloxyphenyl 2-pyridyl ketone

生成物 1

HCID 53784995N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]formamide

実験手順

A mixture of 10.0 g (32.8 mmol) of 3-amino-4-benzyloxyphenyl 2-pyridyl ketone and 200 ml of ethyl formate is refluxed with stirring for 24 hours. The reaction mixture is evaporated and the residue is dissolved in methylene chloride, then is washed with dilute HCl and saturated saline solution. The dried organic phase is evaporated to give 4-benzyloxy-3-formamidophenyl 2-pyridyl ketone.

後処理

  1. temperatureis refluxed
  2. customThe reaction mixture is evaporated
  3. dissolutionthe residue is dissolved in methylene chloride
  4. washis washed with dilute HCl and saturated saline solution
  5. customThe dried organic phase is evaporated

出典と根拠

ORDレコード
ord-1f66b970818545b9a5dd8f3b7f9dc50e
出典データセット
uspto-grants-1976_10
特許番号
US03985887

反応ノート

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