Benzene → 1-Ethynyl-4-methoxynaphthalene

HRID 1287929ノート

反応式

HRID 1287929 の反応式
C1([Li])C=CC=CC=1.Br[CH:9]=[CH:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([O:21][CH3:22])=[CH:13][CH:12]=1.C1C=CC=CC=1>O>[C:10]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([O:21][CH3:22])=[CH:13][CH:12]=1)#[CH:9]

参加物

5

反応物 3

HCID 241BenzeneHCID 544133521-(2-Bromoethenyl)-4-methoxynaphthaleneHCID 178506676HCID 178506676、化合物

生成物 1

HCID 123269971-Ethynyl-4-methoxynaphthalene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Phenyllithium (164 ml. of 2.1 M, 0.345 mol.) was added dropwise to a solution of 35.9 g. (0.138 mol.) of 1-(2-bromoethenyl)-4methoxynaphthalene in 120 ml. of refluxing dry benzene under a nitrogen atmosphere. After addition the reaction mixture was refluxed for 30 minutes, then ice and water were slowly added. The mixture was shaken, the layers separated and the organic phase was washed with water and saturated sodium chloride solution, dried (MgSO4) and evaporated to give 1-ethynyl-4-methoxynaphthalene.

後処理

  1. additionAfter addition the reaction mixture
  2. temperaturewas refluxed for 30 minutes
  3. customthe layers separated
  4. washthe organic phase was washed with water and saturated sodium chloride solution
  5. dry with materialdried (MgSO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-b5415cf9ad40412ea1b94a460feec1d8
出典データセット
uspto-grants-1976_10
特許番号
US03985896

反応ノート

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