Benzene → HCID 21503115、化合物

HRID 1287944ノート

反応式

HRID 1287944 の反応式
Cl.[CH2:2]([O:9][CH2:10][C:11]([CH3:15])([OH:14])[CH2:12][OH:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:16]([O:21][CH2:22][CH3:23])(=[O:20])[C:17]([CH3:19])=O.C1C=CC=CC=1>O>[CH2:2]([O:9][CH2:10][C:11]1([CH3:15])[CH2:12][O:13][C:17]([CH3:19])([C:16]([O:21][CH2:22][CH3:23])=[O:20])[O:14]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 12041Ethyl pyruvateHCID 561596HCID 561596、化合物

生成物 1

HCID 21503115HCID 21503115、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

Dry hydrogen chloride gas was passed into a mixture of 3-benzyloxy-2-methylpropane-1,2-diol (14.9 grams) and ethyl pyruvate (9.15 grams) for 1 hour. The mixture was heated at 90° C for a further 1 hour and then cooled to 50° C. Benzene (100 milliliters) was added to the mixture and the water formed in the reaction was removed azeotropically. The cooled solution was washed with potassium carbonate solution and dried. The solvent was removed under reduced pressure and the residue was fractionally distilled to yield the desired product boiling point 124-126° C at 0.3 Torr.

後処理

  1. temperaturecooled to 50° C
  2. customwas removed azeotropically
  3. washThe cooled solution was washed with potassium carbonate solution
  4. customdried
  5. customThe solvent was removed under reduced pressure
  6. distillationthe residue was fractionally distilled

出典と根拠

ORDレコード
ord-193c57e2116f41b98b2d7f0c42b1b34e
出典データセット
uspto-grants-1976_10
特許番号
US03986860

反応ノート

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