4-(2-Chloro-2-cyanoethyl)benzoic acid → 4-(2-Cyanoethyl)benzoic acid

HRID 1287957ノート

反応式

HRID 1287957 の反応式
Cl[CH:2]([C:13]#[N:14])[CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1>[Zn].C(O)(=O)C>[C:13]([CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:14]

参加物

4

反応物 1

HCID 508886404-(2-Chloro-2-cyanoethyl)benzoic acid

生成物 1

HCID 198791964-(2-Cyanoethyl)benzoic acid

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

実験手順

100 parts of zinc powder are gradually added to a solution of 209.5 parts of 4-(2-chloro-2-cyanoethyl) benzoic acid in 500 parts of glacial acetic acid. The temperature rises quickly up to reflux and is maintained for approximately 1 hour. The solution is filtered when hot so a to eliminate the insoluble matter, then the filtrate is diluted with 1000 parts of water and the precipitate formed is isolated. Thus 122 parts of 4-(2-cyanoethyl) benzoic acid are obtained. M.P.: 182° C.

後処理

  1. temperatureto reflux
  2. temperatureis maintained for approximately 1 hour
  3. filtrationThe solution is filtered when hot so
  4. additionthe filtrate is diluted with 1000 parts of water
  5. customthe precipitate formed
  6. customis isolated

出典と根拠

ORDレコード
ord-fd18203542204cbcac75390e6de83719
出典データセット
uspto-grants-1976_10
特許番号
US03987027

反応ノート

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